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KMID : 0613820080180111606
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Journal of Life Science
2008 Volume.18 No. 11 p.1606 ~ p.1611
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Regulation of an Outer Membrane Protein, OmpW, Expression and Its Biological Function in Salmonell typhimurium
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Yoo Ah-Young
Yu Jong-Earn
Yang Ji-Seon
Kim Young-Hee
Baek Chang-Ho
Oh Jeong-Il
Kang Ho-Young
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Abstract
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Outer membrane proteins (OMPs) expressed in the Gram negative bacteria such as Salmonella play multiple functions including material transports, adhesive factors and reception of external signals. This study has been focused on an OmpW protein known as a protein required to form a hydrophobic porin in outer membrane. We have constructed a S. typhimurium CK10 mutant deleting an ompW gene on chromosome. The CK10 strain was more tolerant to SDS than the wild-type strain did. As increase of salt concentration in the culture media, significantly decreased amount of OmpW protein in cells were detected. The maximum OmpW protein was expressed in the absence of salt supplement. However, the growth of CK10 strain was indistinguishable compared to that of the wild-type strain at the variable osmotic conditions. The biological role of differential OmpW expression in response to osmotic conditions remains to be investigated.
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KEYWORD
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Salmonella typhimurium, OmpW, outer membrane protein
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